Home / Source hierarchy
Written by Kim Callender, NP, FNP-BC·Published July 12, 2026·Last reviewed September 4, 2026·Methodology v1.0

Source hierarchy

Which sources we treat as evidence, in what order, and which we refuse to treat as evidence at all.

The hierarchy

  1. FDA — drug labels, safety communications, databases, declaratory orders, official guidance. Authoritative for regulatory status.
  2. NIH / PubMed-indexed original research — primary evidence for efficacy and safety.
  3. ClinicalTrials.gov — trial design, population, registration. Not a source for results.
  4. Systematic reviews and meta-analyses — strongest for synthesis across trials.
  5. Professional society guidelines — for standard of care.
  6. Government sources — CDC, CMS, the NPI registry, state pharmacy and medical boards. For verifying entities, clinicians and licences.
  7. A provider's own pages — for that provider's prices and service claims only. Never as evidence of its own quality.

What we refuse to treat as evidence

How far a result actually stretches

The most common failure in this field is not misquotation. It is extrapolation — a real result stretched past the population, dose, duration or dosage form that was actually tested.

Every efficacy figure for GLP-1 medications comes from an FDA-approved subcutaneous injection. None was collected on a compounded preparation, a microdose regimen, or an orally disintegrating tablet. When SURMOUNT's numbers appear on a page selling an ODT, evidence has been moved across a dosage form without justification. Every study page we publish carries a 'what this does not prove' section for exactly that reason.

We do not invent citations

We do not invent a study, an author, a DOI, a PMID, a trial registration number or a result. Where we lack a source, we say so. Where a price is unverified, we label it unverified rather than publishing a plausible-looking figure. This sounds like a low bar. In this category it is not.

How this works in practice

A policy that is not operationalised is decoration. Here is what ours actually changes about the pages you read.

Every price carries a status. Verified means we hold a dated capture of the provider's own page. Reported — pending verification means a provider or third party reports it and we have not captured it ourselves. Evaluation in progress means we are not asserting it. We do not upgrade a price to Verified because a comparison site published it — sites in this category contradict each other routinely, and a number repeated by three affiliate blogs is still one unverified number.

Every medical claim traces to a primary source. FDA labels and guidance for regulatory status; PubMed-indexed randomised trials for efficacy; ClinicalTrials.gov for trial design. Reddit and patient forums are never used as evidence of price, safety, efficacy or legitimacy — they may be described as anecdotal sentiment, labelled as such. Animal research is never presented as proof of a human clinical effect.

Every ranking shows its arithmetic. Where a provider we have a commercial relationship with ranks well, the calculation that produced that result is printed on the page. If the arithmetic is wrong, you can see that it is wrong, and tell us.

Commercial relationships and what they do not buy

The publisher and certain principals have financial relationships with some of the telehealth providers listed on this site, and That is how this publication is funded, and we state it in the footer of every page rather than burying it.

What compensation does not do: it does not change a score, a rank, an inclusion decision, or a negative finding. Providers cannot pay for placement, cannot suppress an accurate criticism, and cannot review their own page before publication. Where a commercially-related provider loses a category, we say so — a comparison in which one provider wins everything is an advertisement, and the fastest way to tell the difference is to look for the losses.

Corrections

We publish prices in a market that changes them frequently, and we will get things wrong. When we do, we correct the page, date the correction, and say what changed — we do not quietly edit a number and pretend it was always right. Both readers and providers can submit corrections with evidence, through the same process and to the same standard.

Our own record so far includes removing a set of provider prices we had sourced from a third-party comparison site and could not substantiate, and correcting brand-pricing figures that had gone stale after a manufacturer price cut. Both corrections made the site less flattering to conclusions we had already published. That is the point.

SURMOUNT-1 — mean body-weight reduction by tirzepatide dose, 72 weeks
06111723Placebo3%Tirzepatide 5mg15%Tirzepatide 10mg20%Tirzepatide 15mg21%

Jastreboff AM et al., N Engl J Med 2022 (NCT04184622), n=2,539. Dose-response is real: the effect rises with dose. These are FDA-APPROVED SUBCUTANEOUS INJECTION doses — they do not transfer to compounded, microdose or ODT products. Trial means are not individual promises.

Sources

  1. FDA — human drug compounding and GLP-1 status. fda.gov/drugs/human-drug-compounding
  2. Pricing and program data captured from provider sites and major publishers (Forbes Health, U.S. News), July 2026. Full records: evidence ledger.
  3. Methodology: price-index and affordability methodology.

The numbers behind this page

How this page is kept current

Every price quoted in this page comes from the programme's own pricing page and carries the date it was captured. Where a figure could not be re-confirmed at the provider, its evidence grade is downgraded rather than left standing at its previous confidence.

Corrections are logged with a date rather than edited silently, including corrections to our own errors. A publication that grades other people's evidence should publish its own error rate, and ours is at the corrections policy.

No provider pays for placement, position or inclusion here. Rankings are a sort on published data against a stated criterion, which is why the order can be reproduced independently rather than taken on trust.

Reading the price against the market

Why the spread is this wide

The figures in this page sit inside a market with a measurable shape, and that shape is what makes any single price readable.

The molecule is chemically identical across every programme in the range. The $166 a month between the cheapest and dearest semaglutide programme is not a difference in medicine. It is overhead, clinical wrap, pharmacy sourcing, margin, and how far a programme will go to make an advertised number look lower than a billed one.

Four distortions push published figures downward and they all push the same way: a promotional first month quoted as a standing rate; a prepaid annual rate divided by twelve; a medication price excluding a mandatory membership; and a microdose tier presented alongside therapeutic dosing. Each is individually defensible and together they compound.

Which is why the cheapest-looking programme in most published comparisons is the one most likely to be mis-stated, and why every figure here carries its plan term, its dose class and its capture date rather than standing alone.

Why the spread is this wide

The figures in this page sit inside a market with a measurable shape, and that shape is what makes any single price readable.

The molecule is chemically identical across every programme in the range. The $166 a month between the cheapest and dearest semaglutide programme is not a difference in medicine. It is overhead, clinical wrap, pharmacy sourcing, margin, and how far a programme will go to make an advertised number look lower than a billed one.

Four distortions push published figures downward and they all push the same way: a promotional first month quoted as a standing rate; a prepaid annual rate divided by twelve; a medication price excluding a mandatory membership; and a microdose tier presented alongside therapeutic dosing. Each is individually defensible and together they compound.

Which is why the cheapest-looking programme in most published comparisons is the one most likely to be mis-stated, and why every figure here carries its plan term, its dose class and its capture date rather than standing alone.

Questions this page answers

Why do the same programmes quote two different prices?

Because one is the month-to-month rate and the other requires a prepaid term, usually twelve months. We rank on the month-to-month figure and state the prepaid rate separately, since a rate requiring a year's commitment is not the same offer.

Where do these prices come from?

Each is read from the programme's own published pricing page and carries its capture date. The full set of 24 standard-dose records is at /api/prices.json with molecule and dose class on every record.

What is the cheapest verified GLP-1 programme?

NexLife at $119 a month for semaglutide and $139 for tirzepatide on its 12-month plan, both at standard therapeutic dosing and first-party verified September 4, 2026. Month-to-month, NexLife is $139 and $169; Oak Longevity ($133, flat, no membership) is the next-cheapest semaglutide programme.

Are compounded GLP-1 medicines FDA-approved?

No. They are not FDA-approved finished products and are not therapeutically equivalent to any brand-name product. FDA does not review them for safety, effectiveness or manufacturing quality before marketing.