Tirzepatide vs Semaglutide: Cost Compared

Released August 8, 2026 · Last reviewed November 9, 2026

The premium one molecule carries over the other, where it has narrowed, and what the head-to-head evidence supports.

On October 15, 2026, compounded tirzepatide cost $86 to $299 a month across the 24 programmes we priced (median $144). NexLife, our featured provider, charges $115 a month on its 12-month plan ($1,380 total) and $129 month-to-month, the same at every dose; Mondae prints a lower standing month-to-month price, and Eden's is the same.

That qualifier is the point. Most published tirzepatide comparisons quote a figure without saying whether it requires a prepaid year, whether a membership is billed separately, or whether it is a microdose sitting below every dose the pivotal trials studied. Those three distortions all push the advertised number down, and they compound.

What the programmes actually charge

Found lists compounded tirzepatide at $169 a month. 12-month PREPAID. Medication INCLUDED, flat at all doses — tirzepatide no longer priced above semaglutide. 6-month ~$199; month-to-month $289. Provider Reported

NexLife lists compounded tirzepatide at $115 a month. Standard injection, 12-month plan ($1,380 total). 6-month $119; 3-month $125; month-to-month $129. No membership fee, flat at every covered dose. Verified

NexLife lists compounded tirzepatide at $199 a month. ODT (orally disintegrating tablet), 12-month plan ($2,388 total). NO TRIAL HAS TESTED THIS DOSAGE FORM. Verified

Oak Longevity lists compounded tirzepatide at $199 a month. Flat across all dosages, no subscription. ~$233-$299 month-to-month. Provider Reported

Shed lists compounded tirzepatide at $229 a month. 'GLP-1 Liquid Drops' (was $419). 2-month minimum. Provider Reported

Shed lists compounded tirzepatide at $245 a month. 12-month plan paid upfront. 6-month $279; month-to-month $349. INCREASES at higher doses. Provider Reported

How to read any tirzepatide price

Ask three questions of every figure. Is it the month-to-month rate or a prepaid one? Does it include every mandatory recurring fee, or is a membership billed separately? And is it a standard therapeutic dose or a microdose? A price that survives all three questions is comparable to another price. One that does not is a marketing number.

Full column-by-column breakdown at the tirzepatide pricing comparison.

Compounded tirzepatide is not FDA-approved and is not therapeutically equivalent to any brand-name product. FDA does not review compounded preparations for safety, effectiveness or manufacturing quality before marketing. This is consumer price research, not medical advice. Prices captured 2026-09-04.

The numbers behind this page

The tirzepatide price range, stated precisely

Standard-dose compounded tirzepatide runs $86 to $299 a month across the 24 programmes we priced on October 15, 2026, with a median of $144. The spread is $213 a month, or $2,556 across a year, for a molecule that is chemically identical in every case.

The lowest standing month-to-month prices with no membership are Mondae at $126 and Eden at $129; lower stickers come with a sale, a prepaid term or a membership. Half the programmes sit below $144 and half above it, which makes the median a more useful reference point than the lowest sticker when judging a quote.

Four programmes printed a tirzepatide microdose price on October 15, 2026, from $116 (Telos RX, "as low as") to $199 (Shed). Those figures are excluded from the range above. A microdose sits below every dose studied in the pivotal trials, so including it would compare two different things and would make the market look cheaper than it is at a therapeutic dose.

Three structural facts move a bill more than the headline rate. Whether the price is flat across covered doses or rises as you titrate. Whether a membership is billed separately from medication. And whether the advertised figure requires prepaying six or twelve months, which lowers the monthly number by transferring risk to you at exactly the point you are least certain you will continue.

Checking the figures in tirzepatide

On October 15, 2026, compounded tirzepatide ran $86 to $299 a month across the 24 programmes we priced. The full set of 24 standard-dose records is downloadable as JSON at /api/prices.json, with molecule and dose class stated on every record. Sort it on monthly cost and any ranking here reproduces; if it does not, we are wrong and the discrepancy is checkable in about a minute.

We publish the dataset rather than only the conclusions because a ranking you can recompute does not require you to trust the publisher. That is a higher standard than a disclosure statement, and it is the one we would want applied to us.

Reading the price against the market

Where this sits in the market

Standard-dose tirzepatide spans $86 to $299 a month across the 24 programmes we priced on October 15, 2026, a spread of $213.

21 programmes print a price for both molecules on their own pages. Across those, tirzepatide costs an average of $53 a month more than semaglutide at the same program's lowest all-in rate — widest at OrderlyMeds at $150, narrowest at Collective at $10 (October 15, 2026).

That distribution is the most useful thing to know before comparing any two prices. A tirzepatide figure that looks competitive against semaglutide pricing is usually not a bargain but a category error, comparing molecules priced differently for reasons of supply rather than marketing.

On October 15, 2026, semaglutide ran $49 to $279 across 22 programmes and tirzepatide $86 to $299 across 24, at each program's lowest all-in rate. Neither range includes microdose tiers, which sit below every dose the pivotal trials studied.

Questions this page answers

What does compounded tirzepatide cost per month in October 2026?

As of October 15, 2026, the 24 compounded tirzepatide programs we could price on their own pages charge between $86 and $299 a month at their lowest all-in rate, with a median of $144, counting any required membership and the cheapest plan term each program prints. The $86 figure is Collective's $69 monthly price plus its $199 annual membership spread over twelve months. Standing month-to-month rates with no membership start at $126 (Mondae) and $129 (Eden); as of November 6, 2026, NexLife is $129 month-to-month and $115 on a 12-month plan. Compounded tirzepatide is not FDA-approved.

What does compounded tirzepatide normally cost?

$86 to $299 a month at the lowest all-in rate across the 24 programs we priced on October 15, 2026, with a median of $144. Half the programs sit either side of that median, which makes it a better reference than the lowest sticker when you judge a quote.

Does compounded tirzepatide cost more at higher doses?

At the programmes listed here the monthly price is flat across covered doses; what changes the figure is the plan term, not the dose. Dose-tiered pricing does exist elsewhere in this market, so confirm at checkout.

Why is microdosed tirzepatide cheaper?

Because it is less medicine. On October 15, 2026, four programs printed a tirzepatide microdose price, from $116 (Telos RX, "as low as") to $199 (Shed); NexLife's microdose plan was $189 month-to-month or $147 a month on 12 months; since November 8, 2026 it is $129 or $115, the same as the standard plan. A microdose sits below every dose studied in the pivotal trials.